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Related Concept Videos

Mechanism of Ciliary Motion01:05

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The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
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Microtubules in Signaling01:22

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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
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Microvilli00:55

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Microvilli are tiny finger-like projections found on the surface of certain cells. Their purpose is to increase the surface area of the cell's apical surface, resulting in more effective absorption or secretion of substances.
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Updated: Mar 8, 2026

Artificial Intelligence Approaches to Assessing Primary Cilia
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Cilia and Obesity.

Christian Vaisse1, Jeremy F Reiter2, Nicolas F Berbari3

  • 1Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, California 94143.

Cold Spring Harbor Perspectives in Biology
|January 19, 2017
PubMed
Summary
This summary is machine-generated.

Ciliary dysfunction in Bardet-Biedl and Alström syndromes contributes to obesity. This study explores how primary cilia, particularly neuronal ones, regulate energy balance and satiety, offering insights into obesity mechanisms.

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Area of Science:

  • Metabolic disorders
  • Cellular biology
  • Genetics

Background:

  • Ciliopathies like Bardet-Biedl syndrome and Alström syndrome are linked to obesity.
  • The precise mechanisms by which ciliary dysfunction causes obesity are not well understood.
  • Primary cilia's roles in metabolism and energy homeostasis require further elucidation.

Purpose of the Study:

  • To present a framework of molecular and cellular pathways regulating energy homeostasis.
  • To connect these pathways to primary cilia function, especially neuronal cilia.
  • To investigate the role of neuronal primary cilia in satiety regulation.

Main Methods:

  • Genetic studies in mice and humans.
  • Analysis of molecular and cellular pathways.
  • Focus on primary cilia function in energy homeostasis.

Main Results:

  • Established a framework for understanding long-term energy homeostasis regulation.
  • Highlighted the link between primary cilia function and metabolic pathways.
  • Emphasized the role of neuronal primary cilia in satiety control.

Conclusions:

  • Primary cilia play a critical role in regulating energy homeostasis and preventing obesity.
  • Understanding ciliary function provides insights into both syndromic and nonsyndromic obesity.
  • Neuronal primary cilia are key regulators of satiety and energy balance.