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VITRECTOMY FOR PERSISTENT MACULAR HOLES FOLLOWING OCRIPLASMIN INJECTION: A Comparative Multicenter Study.
Ricarda G Schumann1, Armin Wolf1, Hans Hoerauf2
1Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
Retina (Philadelphia, Pa.)
|January 19, 2017
Summary
Pars plana vitrectomy effectively treats persistent full-thickness macular holes (MH) after ocriplasmin injection, showing significant visual improvement. Outcomes are comparable to direct vitrectomy without prior ocriplasmin treatment.
Area of Science:
- Ophthalmology
- Retinal Surgery
Background:
- Persistent full-thickness macular holes (MH) can occur after intravitreal ocriplasmin injection.
- Pars plana vitrectomy (PPV) is a surgical option for these cases.
Purpose of the Study:
- To evaluate functional and anatomical outcomes of PPV for persistent MH following ocriplasmin treatment.
- To compare these outcomes with eyes undergoing PPV without prior ocriplasmin.
Main Methods:
- Multicenter retrospective study of 37 eyes treated with PPV after ocriplasmin and 35 control eyes.
- Comparison of visual acuity and MH closure rates between groups.
- Matched-pair analysis based on baseline MH diameter.
Main Results:
- No significant difference in postoperative visual acuity between ocriplasmin-treated and control eyes.
- Macular hole closure rates were similar (97% vs. 94%).
- Ocriplasmin injection led to significant MH enlargement prior to surgery.
Conclusions:
- Pars plana vitrectomy yields significant visual improvement for persistent MH post-ocriplasmin.
- Functional and anatomical outcomes of PPV are comparable regardless of prior ocriplasmin treatment.
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