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Vemurafenib (BRAF Inhibitor) Therapy for Orbital Erdheim-Chester Disease
Adit Gupta1, Amir Yeganeh, Daniel Rootman
1*Stein Eye Institute, Division of Orbital and Oculoplastic Surgery, University of California, Los Angeles, and †Doheny Eye Institute, Los Angeles, California, U.S.A.
Abstract:
Erdheim-Chester disease is a rare xanthogranulomatous systemic disease, which involves the orbit in some cases. Through this case report, the authors review the treatment modalities used in orbital Erdheim-Chester disease and explore a newer modality of treatment. Cases of orbital Erdheim-Chester disease were identified in the literature utilizing a PubMed search and all the treatment modalities were reviewed. The response to treatment of orbital Erdheim-Chester disease has been poor with the various medical and surgical treatment modalities used in the past. The authors report the use of BRAF inhibitor with a remarkable response in our case.
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