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Genome Editing in Mammalian Cell Lines using CRISPR-Cas
Published on: April 11, 2019
23.4K
The commercialization of genome-editing technologies
Katelyn Brinegar1,2, Ali K Yetisen1,2,3, Sun Choi2
1a Harvard-MIT Division of Health Sciences and Technology , Massachusetts Institute of Technology , Cambridge , MA , USA.
Critical Reviews in Biotechnology
|January 20, 2017
Summary
Clustered regularly interspaced short palindromic repeats (CRISPR) technology has become dominant in gene editing, driven by academic research and leading to a surge in biotech investment and innovation. This revolution faces challenges from intellectual property, public perception, and regulations.
Area of Science:
- Biotechnology
- Genetics
- Bioengineering
Background:
- Gene-editing technologies are transforming therapeutics, agriculture, and industrial biotechnology.
- Clustered regularly interspaced short palindromic repeats (CRISPR) has emerged as a dominant gene-editing technology.
- CRISPR's development has been pioneered by academic research institutions, unlike earlier industry-led techniques.
Purpose of the Study:
- To analyze the patent landscape of gene-editing technologies.
- To assess the impact of CRISPR on the biotechnology sector and investment.
- To identify factors influencing the growth of genome-editing bioenterprises.
Main Methods:
- Patent landscape analysis of gene-editing technologies.
- Evaluation of investment trends in genome-editing bioenterprises.
- Review of market drivers and potential limitations.
Main Results:
- CRISPR has achieved dominance over earlier gene-editing techniques.
- Academic institutions are leading CRISPR innovation and company spinouts, shifting entrepreneurship strategies.
- Genome-editing bioenterprise investment has increased fivefold, indicating a biotechnology revolution.
- Demand for personalized medicine, GMO crops, and biofuels fuels growth.
Conclusions:
- CRISPR technology is driving significant advancements and investment in biotechnology.
- Academic-led entrepreneurship is reshaping the biotech landscape.
- Market growth may be constrained by intellectual property monopolization, public perception, and regulatory uncertainty.
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