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Cerebral Gluconeogenesis and Diseases.
James Yip1, Xiaokun Geng2, Jiamei Shen3
1Department of Neurosurgery, Wayne State University School of Medicine Detroit, MI, USA.
Frontiers in Pharmacology
|January 20, 2017
Summary
Gluconeogenesis, a glucose-producing pathway, is found in brain astrocytes and may offer an alternative energy source for neurons. Further research is needed to determine its role in brain conditions like stroke and tumors.
Area of Science:
- Neuroscience
- Metabolic Biochemistry
Background:
- Gluconeogenesis, a pathway producing glucose, is typically found in the liver, kidney, intestine, and muscle.
- While present in astrocytes, its role in neurons remains unclear, despite astrocytes utilizing glycolysis to support neuronal energy needs.
Approach:
- This review synthesizes current research on brain gluconeogenesis, particularly in astrocytes.
- It examines the enzymes and regulatory mechanisms involved in this pathway within the central nervous system.
Key Points:
- Astrocytes possess key enzymes for gluconeogenesis and play a role in shuttling lactate to neurons.
- This pathway provides an alternative glucose source for neurons, especially during conditions like ischemic stroke and brain tumors.
- Limited studies exist on cerebral gluconeogenesis compared to cerebral glycolysis.
Conclusions:
- The role of brain gluconeogenesis in pathological conditions such as ischemic stroke and brain tumors requires further investigation.
- Understanding and targeting this pathway could lead to novel therapeutic strategies for brain diseases.
Keywords:
gliomagluconeogenesisglycolysislactatemetastatic breast cancerpyruvate recyclingstroketumor-infiltrating lymphocytesMore Related Videos
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