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Ultrastructural changes during lung carcinogenesis-modulation by curcumin and quercetin.

Xin Wang1, Lei Wang2, Hao Zhang2

  • 1Department of Thoracic Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu 221009, P.R. China; Department of Thoracic Surgery, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China; Department of Thoracic Surgery, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.

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Curcumin and quercetin protect against lung cancer changes. Combined, these natural compounds significantly preserve lung tissue structure and cellular integrity during benzo[a]pyrene-induced lung carcinogenesis in mice.

Keywords:
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Area of Science:

  • Biochemistry
  • Cell Biology
  • Toxicology

Background:

  • Lung carcinogenesis is a complex process involving significant cellular and tissue damage.
  • Benzo[a]pyrene (BP) is a known environmental carcinogen that induces lung cancer in experimental models.
  • Phytochemicals like curcumin and quercetin are investigated for their potential chemopreventive properties.

Purpose of the Study:

  • To evaluate the protective effects of curcumin and quercetin against benzo[a]pyrene-induced lung carcinogenesis.
  • To examine the impact of these compounds on ultrastructural changes in lung tissue.
  • To determine if combined supplementation offers superior protection compared to individual administration.

Main Methods:

  • Mice were divided into five groups: control, BP-treated, BP+curcumin, BP+quercetin, and BP+curcumin+quercetin.
  • Lung carcinogenesis was induced via a single intraperitoneal injection of benzo[a]pyrene (100 mg/kg).
  • Curcumin (60 mg/kg) and quercetin (40 mg/kg) were administered in drinking water.

Main Results:

  • Benzo[a]pyrene treatment caused cellular disruptions, nuclear deformation, and premature mitochondrial aging in lung tissue.
  • Individual supplementation with curcumin or quercetin partially improved lung ultra-histoarchitecture.
  • Combined curcumin and quercetin supplementation demonstrated significant preservation of lung histoarchitecture and ultra-histoarchitecture.

Conclusions:

  • Combined curcumin and quercetin supplementation effectively mitigates ultrastructural damage during BP-induced lung carcinogenesis.
  • These phytochemicals play a crucial role in preserving lung tissue integrity at both histological and ultrastructural levels.
  • The synergistic effect of curcumin and quercetin suggests their potential as chemopreventive agents against lung cancer.