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Complete Resolution of Tumor Burden of Primary Cardiac Non-Hodgkin's Lymphoma
Rina Mauricio1, Ofole Mgbako1, Adam Buntaine1
1Departments of Medicine and Pathology, New York University School of Medicine, New York City, NY, USA.
Insights
Primary cardiac non-Hodgkin's lymphoma (PCL) is rare. This case study shows a patient with extensive PCL achieved complete remission with chemotherapy, with the mass resolving in nine weeks.
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- Primary cardiac tumors are rare neoplasms of the heart or pericardium.
- Primary cardiac non-Hodgkin's lymphoma (PCL) is an exceptionally uncommon diagnosis within this group.
Observation:
- A patient presented with nonspecific symptoms later diagnosed with extensive PCL involving the right ventricle, right atrium, and right ventricular outflow tract.
- The tumor encased the right coronary artery, leading to ischemic changes detected by EKG and cardiac MRI.
Findings:
- The patient received chemotherapy, resulting in complete remission.
- Repeat echocardiography at nine weeks demonstrated dramatic and full resolution of the cardiac mass.
Implications:
- This case highlights chemotherapy as an effective treatment for PCL.
- Further research is necessary to establish optimal management strategies and prognosis for PCL patients.
Abstract:
Primary cardiac tumors are a rare set of benign and malignant neoplasms found in the heart or pericardium. We describe a patient presenting with nonspecific symptoms and ultimately diagnosed with primary cardiac non-Hodgkin's lymphoma (PCL). Our patient had extensive tumor in the right ventricle, which extended into the right atrium and right ventricular outflow tract. The tumor also encased the right coronary artery, which manifested as ischemic changes on EKG and cardiac MRI. The patient was treated with chemotherapy and achieved complete remission, with dramatic and full resolution of the mass on repeat echocardiography in nine weeks. More studies are needed to understand the optimal management and prognosis of patients with PCL.
