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Expression Profile of Long Noncoding RNAs in Human Earlobe Keloids: A Microarray Analysis.

Liang Guo1, Kai Xu1, Hongbo Yan1

  • 1Department of Plastic Surgery, Wuhan General Hospital of Guangzhou Military Command of Chinese PLA, Wuhan, Hubei, China.

Biomed Research International
|January 20, 2017
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Summary

This study identified numerous differentially expressed long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) in earlobe keloid tissues. These findings suggest lncRNAs could be potential diagnostic biomarkers for keloid therapy.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Dermatology

Background:

  • Long noncoding RNAs (lncRNAs) are crucial in biological processes, and their dysregulation is linked to diseases like keloids.
  • The molecular mechanisms underlying earlobe keloid development are not well understood.

Purpose of the Study:

  • To investigate the expression profiles of lncRNAs and mRNAs in earlobe keloids.
  • To identify potential molecular markers for earlobe keloid diagnosis and therapy.

Main Methods:

  • Microarray analysis was employed to compare lncRNA and mRNA expression in earlobe keloid versus normal tissues.
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed.

Main Results:

  • A significant number of lncRNAs (2068) and mRNAs (1511) were found to be differentially expressed.
  • 1290 lncRNAs and 1092 mRNAs were upregulated, while 778 lncRNAs and 419 mRNAs were downregulated.
  • Pathway analysis indicated associations between differential expression and specific biological pathways.

Conclusions:

  • The study provides a comprehensive characterization of lncRNA and mRNA expression in earlobe keloids.
  • lncRNAs show potential as diagnostic biomarkers for earlobe keloid treatment.