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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.1K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Related Experiment Video

Updated: Mar 8, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

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Myeloid Cells in Asthma.

Bart N Lambrecht1,2, Emma K Persson1, Hamida Hammad1,2

  • 1VIB Center for Inflammation Research, Ghent University, 9000 Gent, Belgium.

Microbiology Spectrum
|January 20, 2017
PubMed
Summary

Myeloid cells are key players in asthma pathogenesis, involved in allergic responses and airway inflammation. New targeted therapies are helping researchers understand their specific roles in chronic asthma.

Area of Science:

  • Immunology
  • Pulmonology
  • Cell Biology

Background:

  • Asthma is a complex airway inflammation with myeloid cell involvement.
  • Dendritic cells initiate adaptive immunity, while eosinophils, mast cells, and basophils drive allergic responses and airway remodeling.
  • The roles of neutrophils and macrophages in asthma remain less understood.

Purpose of the Study:

  • To elucidate the specific roles of various myeloid cell populations in the pathogenesis of chronic asthma.
  • To highlight the potential of targeted biological therapies in dissecting myeloid cell functions in asthma.

Main Methods:

  • Review of current literature on myeloid cell involvement in asthma.
  • Discussion of emerging targeted biological therapies for asthma treatment.

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Related Experiment Videos

Last Updated: Mar 8, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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  • Analysis of the impact of specific myeloid cell depletion on asthma pathology.

    • Main Results:

    • Dendritic cells initiate immune responses to allergens.
    • Eosinophils, mast cells, and basophils contribute to type 2 inflammation, airway remodeling, and allergic responses.
    • Targeted biologicals allow for selective elimination of myeloid cell subsets, facilitating functional studies.

    Conclusions:

    • Myeloid cells are critical in asthma pathogenesis, mediating diverse inflammatory and immune responses.
    • Targeted therapies offer unprecedented opportunities to precisely investigate the contribution of individual myeloid cell types to chronic asthma.
    • Further research using these tools is essential for a comprehensive understanding of asthma and development of novel treatments.