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Time-resolved neutron scattering provides new insight into protein substrate processing by a AAA+ unfoldase

Ziad Ibrahim1,2,3,4, Anne Martel4, Martine Moulin4

  • 1Université Grenoble Alpes, Institut de Biologie Structurale, 38044 Grenoble, France.

Scientific Reports
|January 20, 2017
PubMed
Summary

This study introduces a novel method to track protein unfolding and complex structural changes during biochemical reactions in real-time. The technique revealed how AAA+ ATPases mechanically unfold substrates via a reversible power stroke mechanism.

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