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Biophysical profile in fetal triploidy. A case report
J G Lodeiro1, S J Feinstein, K A Bacsik
1Department of Obstetrics and Gynecology, State University of New York Health Science Center, Syracuse.
The Journal of Reproductive Medicine
|August 1, 1989
Summary
A triploid fetus died suddenly after a normal biophysical profile test. Aggressive chromosome analysis is crucial, especially after initial failed attempts, to prevent unexpected fetal demise.
Area of Science:
- Perinatology
- Medical Genetics
Background:
- Fetal growth retardation is a significant concern in pregnancy.
- Biophysical profile (BPP) assessments are standard for evaluating fetal well-being.
- Genetic amniocentesis is a diagnostic tool for chromosomal abnormalities.
Observation:
- A 31-week fetus with pre-existing growth retardation experienced fetal death 24 hours post-reassuring BPP.
- No acute maternal or fetal events were identified as the cause of death.
- Post-delivery, the fetus exhibited features suggestive of triploidy.
Findings:
- Triploidy was confirmed via direct fetal tissue analysis after initial amniotic fluid cell culture failed.
- This case represents the first documented instance of a triploid fetus dying suddenly after a normal BPP.
Implications:
- Sudden fetal death can occur without predictable acute events, even after reassuring BPP results.
- Emphasizes the need for persistent and thorough chromosome analysis, particularly when initial testing is unsuccessful.
- Highlights the limitations of current testing modalities in predicting all causes of fetal mortality.