Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

7.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ku70-SAP domain has an overlapping function with DNA-PKcs in limiting the lateral movement of the Ku ring along DNA.

Nucleic acids research·2026
Same author

Clozapine facilitates sustained improvement in psychotic symptoms with a subsequent cascade of effects on functioning and quality of life.

Journal of psychiatric research·2026
Same author

Diagnostic Uncertainty in Pancreatic Masses: The Critical Role of excluding Malignancy in Suspected Autoimmune Pancreatitis.

Journal of investigative medicine high impact case reports·2026
Same author

Comparison of deep learning and particle smoother EM methods for estimation of Rb-82 myocardial perfusion PET kinetic parameters.

Medical physics·2026
Same author

Maximum likelihood estimation yields accurate line-of-response assignment for positron + prompt gamma ray events in multiplexed PET (mPET).

Biomedical physics & engineering express·2026
Same author

Influence of scintillation light confinement on depth-of-interaction measurement performance in a single-ended readout PET detector.

Physics in medicine and biology·2026

Related Experiment Video

Updated: Mar 8, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

12.8K

Simultaneous PET/MR imaging with a radio frequency-penetrable PET insert.

Alexander M Grant1,2, Brian J Lee2,3, Chen-Ming Chang2,4

  • 1Stanford University, Departments of Bioengineering, Stanford, CA, USA.

Medical Physics
|January 20, 2017
PubMed
Summary

A novel radio frequency (RF)-penetrable positron emission tomography (PET) insert enables simultaneous PET/MRI imaging. This cost-effective insert is compatible with existing MRI systems, increasing PET/MRI accessibility.

Keywords:
PET detectorsPET/MRIRF-penetrableimage reconstructionmultimodalitypositron emission tomography

More Related Videos

MRI and PET in Mouse Models of Myocardial Infarction
10:46

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

12.4K
Simultaneous fMRI and Electrophysiology in the Rodent Brain
08:22

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Published on: August 19, 2010

14.0K

Related Experiment Videos

Last Updated: Mar 8, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

12.8K
MRI and PET in Mouse Models of Myocardial Infarction
10:46

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

12.4K
Simultaneous fMRI and Electrophysiology in the Rodent Brain
08:22

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Published on: August 19, 2010

14.0K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiology

Background:

  • Simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) offers advanced diagnostic capabilities.
  • Integrated PET/MRI scanners are expensive and not widely accessible.
  • A need exists for adaptable PET imaging solutions compatible with existing MRI infrastructure.

Purpose of the Study:

  • To design and evaluate a brain-sized, radio frequency (RF)-penetrable PET insert for simultaneous operation with MRI systems.
  • To enable the use of existing MRI scanners for simultaneous PET/MRI by designing an insert that minimizes RF interference.
  • To utilize electro-optical coupling and battery power for electrical isolation, allowing RF signal transmission through the PET insert.

Main Methods:

  • A PET insert was constructed using nonmagnetic silicon photomultipliers, compressed sensing signal multiplexing, and optical fibers.
  • The insert was tested in a laboratory setting and subsequently within a 3T MRI system.
  • Tomographic images of resolution and contrast phantoms were acquired under various MRI conditions (B0 field only and continuous RF pulsing).

Main Results:

  • The PET insert successfully acquired tomographic images of phantoms in both laboratory and MRI environments.
  • PET images demonstrated comparable contrast-to-noise ratios (CNR) across different MRI pulsing conditions (mean CNR difference of 14.0 ± 7.7%).
  • MR images were acquired without significant interference using the built-in body coil, confirming the feasibility of simultaneous imaging.

Conclusions:

  • The developed RF-penetrable PET insert shows promise as an accessible alternative to integrated PET/MRI scanners.
  • This technology can significantly enhance the availability and dissemination of simultaneous PET/MRI.
  • Compatibility with existing MRI systems could broaden the clinical application of PET/MRI.