Related Experiment Video
Updated: Mar 8, 2026
Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
Published on: March 13, 2015
A Community-Based Randomized Trial of Hepatitis B Screening Among High-Risk Vietnamese Americans
Grace X Ma1, Carolyn Y Fang1, Brenda Seals1
1Grace X. Ma, Brenda Seals, and Yin Tan are with the Center for Asian Health, Lewis Katz School of Medicine, Temple University, Philadelphia, PA. Carolyn Y. Fang and Minhhuyen T. Nguyen are with the Fox Chase Cancer Center, Temple University Medical System, Philadelphia. Ziding Feng is with the Department of Biostatistics, Anderson Cancer Center, University of Texas, Houston. Philip Siu is with Chinatown Medical Services, Philadelphia. Ming Chin Yeh is with the Nutrition Program, Hunter College, City University of New York, New York, NY. Sarit A. Golub is with the Department of Psychology, Hunter College, City University of New York. Tam Tran is with the Viet Community, Asian American Buddhist Association, Philadelphia. Minqi Wang is with the School of Public Health, University of Maryland, College Park.
Objectives:
To evaluate the effectiveness of a community-based liver cancer prevention program on hepatitis B virus (HBV) screening among low-income, underserved Vietnamese Americans at high risk.
Methods:
We conducted a cluster randomized trial involving 36 Vietnamese community-based organizations and 2337 participants in Pennsylvania, New Jersey, and New York City between 2009 and 2014. We randomly assigned 18 community-based organizations to a community-based multilevel HBV screening intervention (n = 1131). We randomly assigned the remaining 18 community-based organizations to a general cancer education program (n = 1206), which included information about HBV-related liver cancer prevention. We assessed HBV screening rates at 6-month follow-up.
Results:
Intervention participants were significantly more likely to have undergone HBV screening (88.1%) than were control group participants (4.6%). In a Cochran-Mantel-Haenszel analysis, the intervention effect on screening outcomes remained statistically significant after adjustment for demographic and health care access variables, including income, having health insurance, having a regular health provider, and English proficiency.
Conclusions:
A community-based, culturally appropriate, multilevel HBV screening intervention effectively increases screening rates in a high-risk, hard-to-reach Vietnamese American population.
