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Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
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Bacterial resistance to antibodies: a model evolutionary study.

Lawrence S Schulman1

  • 1Physics Department, Clarkson University, Potsdam, NY 13699-5820, USA.

Journal of Theoretical Biology
|January 21, 2017
PubMed
Summary

The tangled nature model helps study antibiotic resistance from horizontal gene transfer. Resistant bacterial strains can rapidly emerge and dominate, impacting patient outcomes.

Keywords:
EcologyEvolutionHorizontal gene transferTangled nature

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Area of Science:

  • Evolutionary biology
  • Microbiology
  • Genetics

Background:

  • Antibiotic resistance is a growing public health concern.
  • Horizontal gene transfer plays a significant role in the spread of resistance genes.
  • Understanding the evolutionary dynamics of resistance is crucial.

Purpose of the Study:

  • To adapt the tangled nature model of evolution for studying antibiotic resistance acquisition via horizontal gene transfer.
  • To investigate the proliferation dynamics of resistant bacterial strains under various parameters.

Main Methods:

  • Utilized the tangled nature model of evolution.
  • Simulated DNA exchanges and acquisition of resistant gene sequences.
  • Analyzed genome distribution patterns.

Main Results:

  • Resistant bacterial strains rapidly proliferated and dominated under tested parameters.
  • Initial intense antibiotic treatment could occasionally prevent the dominance of resistant strains.
  • Observed a long-tailed variation in genome distribution.

Conclusions:

  • The model suggests that resistant bacterial strains are expected to occur due to evolutionary processes.
  • Considerable variation in patient outcomes can be anticipated.
  • Horizontal gene transfer significantly contributes to the rapid spread of antibiotic resistance.