Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

CNS Depressants: Alcohol and Nicotine

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

Binge Eating Disorders

Binge Eating Disorders

Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...

Substance Use Disorders Affecting Sleep

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolic dysfunction in multiple sclerosis: Elevated lactate and impaired post-exercise creatine response in the anterior cingulate cortex.

Multiple sclerosis and related disorders·2026

Same author

Risk of dementia after bloodstream infection-a nationwide propensity score matched cohort study.

Age and ageing·2026

Same author

Negative Contextual Valence Unmasks Altered Counterfactual Decision-Making in Major Depressive Disorder.

medRxiv : the preprint server for health sciences·2026

Same author

The functional relevance of a short assessment of formal thought disorder in psychosis.

The British journal of psychiatry : the journal of mental science·2026

Same author

Structural imaging predictors of ketamine response in treatment-resistant depression: a machine learning approach.

Translational psychiatry·2026

Same author

Four Directions, One Solution: Enabling Rapid Diffusion Tensor MRI for Ultra-Low Field Using Deep Learning.

Magnetic resonance in medicine·2026

Same journal

Abuse Potential and Neurotoxic Effects of the Synthetic Cannabinoid 4F-ABUTINACA Self-Administration in Adult Male Rats.

Addiction biology·2026

Same journal

Longitudinal Cognitive Evolution in Alcohol Use Disorder Patients: Role of Inflammation, Time of Abstinence and Apolipoprotein Profile.

Addiction biology·2026

Same journal

The Interplay Between Sleep Disturbance, Glymphatic Dysfunction and Altered Brain Networks in Internet Gaming Disorder: A Multimodal Neuroimaging Study.

Addiction biology·2026

Same journal

Correction to "Learning Mechanisms in Alcohol Use Disorders".

Addiction biology·2026

Same journal

Abnormal Brain Structural Covariance Networks of Cortical Thickness in Cocaine Use Disorder.

Addiction biology·2026

Same journal

The Orexin System Modulates Stress-Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence.

Addiction biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 8, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Binge drinking differentially affects cortical and subcortical microstructure.

Laurel S Morris^1,2, Nicholas G Dowell³, Mara Cercignani³

¹Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.

Addiction Biology

|January 21, 2017

Summary

This summary is machine-generated.

Young adults who binge drink show altered brain microstructure, specifically in regions related to reward and motivation. These changes in neurite complexity may indicate neurodevelopmental impacts from alcohol misuse.

More Related Videos

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

Related Experiment Videos

Last Updated: Mar 8, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

Area of Science:

Neuroscience
Neuroimaging
Addiction Research

Background:

Chronic alcohol use causes neuroplastic changes, affecting reward and motivation centers.
Young adult binge drinking serves as a model for alcohol misuse risk factors.

Purpose of the Study:

To investigate neural microstructure differences in young adult binge drinkers versus healthy controls.
To explore the relationship between alcohol consumption patterns and brain microstructural features.

Main Methods:

Utilized advanced diffusion magnetic resonance imaging (dMRI) with three-compartment modeling.
Assessed neurite density and orientation dispersion index (ODI) in brain tissue.
Compared 28 binge drinkers with 38 matched healthy controls.

Main Results:

Binge drinkers exhibited reduced ODI (neurite complexity) in frontal grey matter and increased ODI in parietal grey matter.
Increased neurite density was observed in cortical white matter adjacent to regions with lower ODI.
Higher ventral striatal grey matter ODI in binge drinkers positively correlated with binge drinking scores.

Conclusions:

Demonstrated disturbed dendritic complexity in prefrontal and parietal regions of binge drinkers.
Identified increased dendritic complexity in the ventral striatum, a reward-related area.
Findings suggest alcohol bingeing impacts neurodevelopmental processes in at-risk young adults.