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Updated: Mar 8, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research

Takehiko Yokobori1, Masahiko Nishiyama2,3

  • 1Research Program for Omics-based Medical Science, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. bori45@gunma-u.ac.jp.

Journal of Clinical Medicine
|January 21, 2017
PubMed

Insights

Transforming growth factor-beta (TGF-β) and its downstream protein, TGFBI, play complex roles in gastrointestinal cancers, influencing progression and treatment resistance.

Area of Science:

  • Molecular biology
  • Oncology
  • Gastroenterology

Background:

  • Transforming growth factor-beta (TGF-β) superfamily proteins regulate critical cellular processes like differentiation, proliferation, and migration.
  • TGF-β signaling is implicated in cancer progression and therapeutic resistance across various malignancies.
  • TGF-β-induced protein (TGFBI), a downstream effector, exhibits dual roles in cancer, potentially promoting or inhibiting tumor development.

Purpose of the Study:

  • To review current basic and clinical research on the roles of TGF-β and TGFBI in gastrointestinal cancers.
  • To synthesize the existing knowledge on the involvement of these key signaling molecules in GI tumorigenesis.

Main Methods:

  • Comprehensive literature review of peer-reviewed articles.
  • Analysis of studies focusing on TGF-β and TGFBI in gastrointestinal cancer models and patient data.
  • Synthesis of findings from basic science and clinical research.

Main Results:

  • TGF-β signaling pathways are frequently dysregulated in gastrointestinal cancers.
  • TGFBI expression levels and functions vary, contributing to distinct cancer phenotypes.
  • Evidence suggests a link between TGF-β/TGFBI signaling and resistance to cancer therapies.

Conclusions:

  • TGF-β and TGFBI are significant players in the pathogenesis and progression of gastrointestinal cancers.
  • Understanding their complex roles is crucial for developing targeted therapeutic strategies.
  • Further research is warranted to elucidate the precise mechanisms and clinical implications in GI oncology.
Keywords:
EMTTGF-β signalingTGFBIgastrointestinal cancertumor promotertumor suppressor

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