Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 8, 2026

Constructing a Low-budget Laser Axotomy System to Study Axon Regeneration in C. elegans
10:05

Constructing a Low-budget Laser Axotomy System to Study Axon Regeneration in C. elegans

Published on: November 15, 2011

16.0K

Atherectomy using a solid-state laser at 355 nm wavelength.

Amir Herzog1, Grzegorz Oszkinis2, David Planer3

  • 1Department of Electrical and Computer Engineering, Ben-Gurion University, Beer-Sheva, Israel.

Journal of Biophotonics
|January 21, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing iatrogenic atrial septal defect as a primary unloading strategy in acute myocardial infarction using computational and swine model.

Scientific reports·2026
Same author

Surgical and Endovascular Management of Pseudoaneurysms of the Ascending Aorta and Aortic Root: Operative Strategies and Long-Term Outcomes.

Aorta (Stamford, Conn.)·2026
Same author

Clinical trial of concomitant vs staged foam sclerotherapy of varicose veins following axial thermal ablation.

Journal of vascular surgery. Venous and lymphatic disorders·2026
Same author

3D Measurement of Chronic Wounds in Routine Care: A Review with Practical Guidance for Smartphone Photogrammetry.

Annals of biomedical engineering·2026
Same author

Electrocardiographic Characteristics of Escape Rhythm During Complete Atrioventricular Block After Transcatheter Aortic Valve Replacement.

Reviews in cardiovascular medicine·2026
Same author

Management of iatrogenic pseudoaneurysm - single-centre experience.

Polski przeglad chirurgiczny·2026
Same journal

Evaluation of the Usefulness of Machine Learning and Artificial Intelligence on Hyperspectral Images in the Diagnosis of Myelodysplastic Syndrome.

Journal of biophotonics·2026
Same journal

Correction to "Characterization of Cerebrovascular Changes in Mice Treated With Alcohol by Photoacoustic Imaging".

Journal of biophotonics·2026
Same journal

Defining Safe Light Intensity Limits of Near-Infrared Illumination Avoiding Skin Heating in Medical Optical Diagnostic Methods.

Journal of biophotonics·2026
Same journal

Review of the SWIR Windows to Study Osteoarthritis.

Journal of biophotonics·2026
Same journal

FTIR-ATR Spectroscopy as a Tool to Differentiate Listeria monocytogenes by Geno-Serogroups, Growth Conditions and Persistence Status.

Journal of biophotonics·2026
Same journal

Utilizing Serum Fluorescence Spectra and Machine Learning Algorithms for Efficient Diagnosis of Sheep Brucellosis.

Journal of biophotonics·2026
See all related articles
This summary is machine-generated.

This study demonstrates a novel laser atherectomy technique for peripheral arterial disease (PAD). The 355 nm pulsed laser successfully recanalized blocked arteries in preclinical and clinical settings, showing promise for PAD treatment.

Area of Science:

  • Cardiovascular Medicine
  • Medical Devices
  • Laser Technology

Background:

  • Peripheral arterial disease (PAD) significantly increases risks of ischemic events, limb loss, and mortality.
  • Atherosclerosis is the primary cause of PAD, often leading to arterial calcification and occlusion.
  • Novel minimally invasive techniques are needed for effective PAD treatment.

Purpose of the Study:

  • To evaluate the efficacy and safety of a 355 nm solid-state pulsed laser delivered via a hybrid catheter for atherectomy.
  • To assess the laser's performance in preclinical models and human clinical cases of chronic total occlusions.

Main Methods:

  • Utilized a hybrid catheter system combining optical fibers and a mechanical blade with a 355 nm solid-state pulsed laser.
  • Conducted a preclinical study on a calcified cadaveric leg and an in vivo porcine iliac artery model.
Keywords:
355 nmPeripheral arterial diseaseatherectomylaser ablationrecanalization

More Related Videos

Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser
07:17

Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser

Published on: May 9, 2018

8.5K
Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
04:43

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation

Published on: May 23, 2025

950

Related Experiment Videos

Last Updated: Mar 8, 2026

Constructing a Low-budget Laser Axotomy System to Study Axon Regeneration in C. elegans
10:05

Constructing a Low-budget Laser Axotomy System to Study Axon Regeneration in C. elegans

Published on: November 15, 2011

16.0K
Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser
07:17

Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser

Published on: May 9, 2018

8.5K
Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
04:43

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation

Published on: May 23, 2025

950
  • Applied the technique to two clinical cases involving chronic total occlusions with calcified lesions.

    • Main Results:

    • Achieved successful recanalization of the occluded cadaveric leg.
    • Porcine study showed no thermal necrosis in histopathology and no arterial wall damage.
    • Animal trials revealed no significant impact on blood count or biochemistry.
    • Both clinical cases resulted in successful arterial recanalization, followed by balloon angioplasty.

    Conclusions:

    • The 355 nm solid-state pulsed laser atherectomy system represents a viable proof of concept for treating PAD.
    • The technique demonstrated safety and efficacy in preclinical and clinical settings for calcified arterial lesions.
    • This laser-based approach offers a promising new option for managing complex PAD cases.