Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

1.7K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.7K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

726
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
726
Inflammation01:38

Inflammation

63.3K
Overview
63.3K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

855
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
855
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.8K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.8K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

540
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
540

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary microvascular dysfunction: a narrative review.

Cardiovascular diagnosis and therapy·2026
Same author

Diagnostic accuracy of photon-counting CT for in-stent restenosis: A preliminary meta-analysis.

Journal of cardiovascular computed tomography·2026
Same author

The gut-heart axis in cardio-oncology.

Cardiovascular research·2026
Same author

Quantitative rapid image-based method for coronary artery blood flow and wall shear stress extraction.

Frontiers in bioengineering and biotechnology·2026
Same author

The asialoglycoprotein receptor 1 (ASGR1): emerging new roles in health and disease.

Biomarker research·2026
Same author

SUpporting Mothers Milk Intervention Trial (SUMMIT) - a randomised controlled trial comparing different doses of domperidone for treating lactation insufficiency in mothers of preterm infants - study protocol.

International breastfeeding journal·2026

Related Experiment Video

Updated: Mar 8, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K

Plaque burden, microstructures and compositions underachieving very low LDL-C levels.

Yu Kataoka1, Jordan Andrews, Rishi Puri

  • 1aDepartment of Cardiovascular Medicine National Cerebral & Cardiovascular Centre, Suita, Japan bHeart Health, South Australian Health & Medical Research Institute, University of Adelaide, Adelaide, Australia cQuebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada.

Current Opinion in Endocrinology, Diabetes, and Obesity
|January 21, 2017
PubMed
Summary

Lowering low-density lipoprotein cholesterol (LDL-C) slows atherosclerotic plaque progression and alters its composition. Achieving very low LDL-C levels with statins promotes plaque regression and improves cardiovascular outcomes.

More Related Videos

Enrichment of Native Lipoprotein Particles with microRNA and Subsequent Determination of Their Absolute/Relative microRNA Content and Their Cellular Transfer Rate
11:13

Enrichment of Native Lipoprotein Particles with microRNA and Subsequent Determination of Their Absolute/Relative microRNA Content and Their Cellular Transfer Rate

Published on: May 9, 2019

9.3K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K

Related Experiment Videos

Last Updated: Mar 8, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K
Enrichment of Native Lipoprotein Particles with microRNA and Subsequent Determination of Their Absolute/Relative microRNA Content and Their Cellular Transfer Rate
11:13

Enrichment of Native Lipoprotein Particles with microRNA and Subsequent Determination of Their Absolute/Relative microRNA Content and Their Cellular Transfer Rate

Published on: May 9, 2019

9.3K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K

Area of Science:

  • Cardiovascular Medicine
  • Atherosclerosis Research
  • Lipid Metabolism

Background:

  • Low-density lipoprotein cholesterol (LDL-C) is a primary target for preventing atherosclerotic cardiovascular disease.
  • Intravascular imaging techniques have provided in vivo evidence of LDL-C lowering's antiatherosclerotic effects.

Purpose of the Study:

  • To review the impact of reducing LDL-C on atherosclerotic plaque progression.
  • To examine how LDL-C lowering affects plaque microstructures and compositions.
  • To synthesize current understanding of LDL-C's role in managing cardiovascular disease.

Main Methods:

  • Review of studies utilizing intravascular imaging to assess atherosclerotic plaques.
  • Analysis of data on the effects of statin therapy and intensive LDL-C control.
  • Synthesis of findings related to plaque progression, microstructure, and composition changes.

Main Results:

  • Intensive LDL-C control, particularly with statins, significantly slows plaque progression.
  • Achieving very low LDL-C levels can induce atherosclerotic plaque regression.
  • Lowering LDL-C modulates plaque microstructures and alters lipid and inflammatory compositions.

Conclusions:

  • Lowering LDL-C is a cornerstone therapy for primary and secondary prevention of cardiovascular events.
  • Mechanistic insights from intravascular imaging confirm the benefits of LDL-C reduction.
  • This review consolidates evidence on LDL-C's multifaceted impact on atherosclerotic disease.