Recent progress, challenges and trends in trace determination of drug analysis using molecularly imprinted...

Area of Science:

• Analytical Chemistry
• Pharmaceutical Analysis
• Materials Science

Background:

• Accurate drug quantification in biological samples is essential for evaluating drug efficacy during discovery.
• Traditional analytical methods face challenges in detecting trace drug levels due to low concentrations and complex matrices.
• Sample preparation remains a critical bottleneck in achieving sensitive and reliable trace analysis.

Purpose of the Study:

• To review the application of molecularly imprinted solid-phase microextraction (MISPME) for trace drug determination.
• To highlight the advantages of combining molecular imprinting and solid-phase microextraction techniques.
• To emphasize the role of MISPME in overcoming challenges in drug analysis.

Main Methods:

• Solid-phase microextraction (SPME) as a solvent-free sample preparation technique.
• Molecularly imprinted polymers (MIPs) for selective molecular recognition.
• Integration of MIPs with SPME to create MISPME for enhanced selectivity and pre-concentration.

Main Results:

• MISPME offers a powerful, simple, and fast approach for sample preparation.
• The combination provides high selectivity and chemical stability for trace analysis.
• MISPME integrates sampling, clean-up, and pre-concentration in a single step.

Conclusions:

• MISPME represents a significant advancement in analytical instrumentation for drug analysis.
• This technique enhances simplicity, flexibility, and selectivity in trace drug determination.
• MISPME is a promising tool for overcoming limitations in current drug analysis procedures.