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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Bullous, pseudobullous, & pustular dermatoses.

Mark R Wick1

  • 1Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States.

Seminars in Diagnostic Pathology
|January 22, 2017
PubMed
Summary
This summary is machine-generated.

This review details skin conditions characterized by blisters or pustules, covering their causes, clinical signs, and histological features for better diagnosis and understanding.

Keywords:
Bullous skin diseasesCutaneous porphyriaDarier diseaseEpidermolysis bullosa acquisitaGrover diseaseHailey-Hailey diseaseHerpes infectionsIgA-mediated dermatosesImpetigoInherited epidermolysis bullosaPemphigoidPemphigusPustular skin diseases

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Several skin diseases are defined by the formation of epidermal spaces, such as blisters and bullae.
  • These lesions can be acellular or contain inflammatory cells, with diverse etiologies including infections, immune responses, genetic factors, drugs, or unknown causes.

Purpose of the Study:

  • To review the clinical and histological characteristics of dermatoses involving epidermal spaces and pustules.
  • To categorize these conditions based on their underlying causes and presentation.

Main Methods:

  • Review of existing literature on blistering and pustular dermatoses.
  • Analysis of clinical presentations and histopathological findings.
  • Categorization of diseases based on etiology (infectious, immune-mediated, genetic, drug-related, idiopathic).

Main Results:

  • Identified key dermatoses with blisters/bullae, including impetigo, herpes infections, pemphigus, bullous pemphigoid, epidermolysis bullosa variants, Hailey-Hailey disease, and porphyria cutanea tarda.
  • Highlighted conditions with microscopic acantholysis but no clinical bullae, such as Darier and Grover diseases.
  • Discussed causes of neutrophilic pustules, including pustular psoriasis, Sneddon-Wilkinson disease, and acute generalized exanthematous pustulosis.

Conclusions:

  • Blistering and pustular dermatoses represent a diverse group of conditions with varied origins and presentations.
  • Understanding the clinical and histological features is crucial for accurate diagnosis and management of these skin disorders.