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Updated: Mar 8, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation

Xavier Gómez-Santacana1, James A R Dalton2, Xavier Rovira3

  • 1MCS, Laboratory of Medicinal Chemistry & Synthesis, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain; Laboratory of Molecular Neuropharmacology and Bioinformatics, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain; Nanoprobes and Nanoswitches, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac, 08028, Barcelona, Spain.

European Journal of Medicinal Chemistry
|January 23, 2017
PubMed

Keywords:
AntagonistInverse agonistIsomersNAMPartial efficacymGlu(5)

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