Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

306
Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
306
Bioavailability: Overview01:13

Bioavailability: Overview

4.8K
Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
4.8K
Bioavailability: Overview01:17

Bioavailability: Overview

624
Bioavailability refers to the proportion of an administered drug that reaches the systemic circulation in its active, unaltered form. It is a crucial pharmacokinetic parameter that determines the effectiveness of a drug in achieving its intended therapeutic outcomes. The route of administration significantly influences bioavailability, with intravenous administration achieving 100% bioavailability as the drug directly enters the bloodstream. In contrast, oral administration often results in...
624
Bioavailability: Influencing Factors01:22

Bioavailability: Influencing Factors

518
Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
518
Bioavailability Study Design: Absolute Versus Relative Bioavailability01:27

Bioavailability Study Design: Absolute Versus Relative Bioavailability

491
Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...
491
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

196
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
196

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "<i>In vitro</i> and <i>in vivo</i> toxicological evaluation of 6'-Sialyllactose sodium salt produced by a novel method" [Toxicol. Rep., Volume 15 (2025) 102101].

Toxicology reports·2026
Same author

Adhering to dietary guidelines does not yield flavanol intake levels associated with beneficial cardiovascular effects.

Food & function·2026
Same author

Evolving Cancer Characteristics Among World Trade Center Survivors: An Updated Analysis from the WTC Environmental Health Center.

International journal of environmental research and public health·2026
Same author

Examining widely held propositions on human dietary protein needs and benefits: a critical review of the science that shapes both the data and our understanding of an essential macronutrient.

Critical reviews in food science and nutrition·2026
Same author

The Urinary Tract commensal <i>Peptoniphilus</i> spp<i>.</i> Encodes a Novel 17β-Hydroxysteroid Dehydrogenase.

bioRxiv : the preprint server for biology·2026
Same author

A Framework for Developing Intake and Use Guidance for Dietary Supplement Bioactives.

Advances in nutrition (Bethesda, Md.)·2026

Related Experiment Video

Updated: Mar 8, 2026

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
06:34

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

5.9K

Bioactive nutrients - Time for tolerable upper intake levels to address safety.

Allison A Yates1, John W Erdman2, Andrew Shao3

  • 1Food and Nutrition Board, Institute of Medicine, National Research Council, Johnson City, TN 37615, United States.

Regulatory Toxicology and Pharmacology : RTP
|January 23, 2017
PubMed
Summary

Consumers, researchers, and regulators are exploring bioactive compounds from natural sources for health benefits. Establishing safe intake levels requires toxicologist involvement in safety assessments and guidance development.

Keywords:
BioactivesDRIsDietary reference intakesEGCGEpigallocatechin gallateGreen teaLuteinNutrient reference valuesNutritionTolerable upper intake levels

Related Experiment Videos

Last Updated: Mar 8, 2026

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
06:34

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

5.9K

Area of Science:

  • Nutritional Science
  • Toxicology
  • Pharmacology

Background:

  • Growing consumer and regulatory interest in bioactive compounds from natural sources (plants, animals) for health.
  • Emerging research suggests health benefits from compounds in fruits, vegetables, tea, cocoa, fish, and probiotics.
  • Need for evidence-based dietary guidance and recommended intakes for bioactive substances.

Purpose of the Study:

  • To explore the establishment of recommended intakes for bioactive substances.
  • To highlight the critical role of safety and toxicity assessments in dietary guidance.
  • To emphasize the necessity of toxicologist involvement in developing safety frameworks.

Main Methods:

  • Review of emerging research on bioactive compounds and their health effects.
  • Analysis of the process for establishing dietary guidance.
  • Identification of toxicological requirements for safety assessments.

Main Results:

  • Significant health benefits are suggested for various bioactive compounds from natural origins.
  • Safety assessment and toxicity evaluation are crucial for setting dietary recommendations.
  • Toxicologists are essential for developing safety frameworks and upper intake limits.

Conclusions:

  • Dietary guidance for bioactive compounds requires robust safety evaluations.
  • Collaboration between researchers and toxicologists is vital for consumer health and safety.
  • Further research and regulatory frameworks are needed to harness the health potential of natural bioactive compounds.