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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Irritable bowel syndrome and diet.
Piero Portincasa1, Leonilde Bonfrate1, Ornella de Bari2
1Clinica Medica A. Murri, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro Medical School, Bari, Italy piero.portincasa@uniba.it.
Irritable bowel syndrome (IBS) management involves lifestyle changes, particularly dietary interventions like low FODMAP diets. This review explores evidence for nutrition-based therapies in treating IBS symptoms.
Area of Science:
- Gastroenterology
- Clinical Nutrition
- Dietary Science
Background:
- Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder with significant impact.
- Complex pathophysiology necessitates symptom-specific and multifaceted treatment approaches.
- Current IBS management includes education, lifestyle modifications, medications, and psychological interventions.
Purpose of the Study:
- To focus on available dietary interventions for IBS.
- To review the evidence supporting nutrition-based therapies for IBS management.
Main Methods:
- Literature review of dietary interventions for IBS.
- Analysis of evidence for nutrition-based therapies, including low FODMAP diets, exclusion of gas-producing foods, lactose, gluten, and fiber supplementation.
- Consideration of nutraceuticals as therapeutic agents.
Main Results:
- Dietary approaches such as low fermentable oligo-, di- and monosaccharides and polyols (FODMAPs) diets are beneficial.
- Exclusion of gas-producing foods, lactose, and gluten may improve symptoms.
- Fiber supplementation can be useful in selected IBS cases.
Conclusions:
- Nutrition-based therapies, especially low FODMAP diets, are key components in IBS management.
- Evidence supports various dietary modifications for symptom relief in IBS patients.
- Nutraceuticals represent a promising area for future IBS treatment strategies.
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