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Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
Published on: October 27, 2023
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Axial spondyloarthritis
Joachim Sieper1, Denis Poddubnyy1
1Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Berlin, Germany.
Lancet (London, England)
|January 24, 2017
Summary
Axial spondyloarthritis, including ankylosing spondylitis, involves inflammation and potential bone damage. Early identification and treatments like TNF blockers and IL-17 blockade are key for managing this condition.
Area of Science:
- Rheumatology
- Immunology
- Genetics
Background:
- Axial spondyloarthritis (AxSpA) encompasses radiographic (ankylosing spondylitis) and non-radiographic forms.
- Onset typically occurs in the third decade, with varying male-to-female ratios.
- High heritability (>90%) is linked to HLA-B27, though its pathogenic role requires further elucidation.
Purpose of the Study:
- To review the pathogenesis, diagnosis, and treatment of axial spondyloarthritis.
- To highlight the roles of key cytokines and the importance of early detection.
- To discuss current and emerging therapeutic strategies.
Main Methods:
- Literature review of clinical trials and pathogenic mechanisms.
- Analysis of genetic associations, particularly HLA-B27.
- Evaluation of diagnostic tools like MRI and therapeutic interventions.
Main Results:
- Tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) are implicated in AxSpA pathogenesis.
- New classification and screening criteria, alongside MRI, aid early patient identification.
- Non-steroidal anti-inflammatory drugs (NSAIDs) and TNF blockers demonstrate efficacy.
Conclusions:
- Understanding the interplay between inflammation and bone formation is crucial for preventing long-term damage.
- IL-17 blockade represents a significant advancement in AxSpA treatment.
- Early diagnosis and targeted therapies, including IL-17 blockade, improve patient outcomes.
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