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Updated: Sep 15, 2026
Two-Photon-Based Photoactivation in Live Zebrafish Embryos
Published on: December 24, 2010
Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in
Moses Bio1, Pallavi Rajaputra, Irene Lim
1Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA. youngjae-you@ouhsc.edu.
Abstract:
Photo-unclick chemistry mediates visible and near IR-controlled drug release via a singlet oxygen (SO)-cleavable linker. Due to the limited diffusion distance of SO in biological systems, a photosensitizer and the SO-cleavable linker have been conjugated in one molecule or mixed in nano-drug delivery systems. In this communication, we demonstrate a new strategy to activate prodrugs with photo-unclick chemistry in an intermolecular fashion using an SO-cleavable CA4 prodrug and a mitochondria-specific photosensitizer, protoporphyrin IX, formed from prodrug hexyl-5-aminolevulinate.
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