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Transdermal Vascular Endothelial Growth Factor Delivery with Surface Engineered Gold Nanoparticles
Ying Chen1, Yonghui Wu1, Jining Gao1
1Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Chongqing Engineering Research Center for Biomaterials and Regenerative Medicine, Third Military Medical University , Chongqing 400038, China.
Gold nanoparticles conjugated with vascular endothelial growth factor (VEGF) show ideal transdermal delivery for wound repair. This novel approach enhances VEGF delivery through the skin barrier, offering new treatment avenues for cutaneous injuries.
Area of Science:
- Biomaterials science
- Dermatology
- Nanotechnology
Background:
- Skin injuries from burns or radiation necessitate effective therapeutic strategies.
- Angiogenesis, or new blood vessel formation, is crucial for skin repair following epidermal or dermal damage.
- Vascular endothelial growth factor (VEGF) promotes angiogenesis but faces delivery challenges due to the skin barrier.
Purpose of the Study:
- To investigate the efficacy of gold nanoparticle (AuNP)-mediated transdermal delivery of VEGF for wound repair.
- To develop a method for overcoming the skin barrier to enhance VEGF delivery to cutaneous injury sites.
Main Methods:
- Gold nanoparticles (AuNPs) were conjugated with VEGF.
- The surface properties of the VEGF-conjugated AuNPs were modified to carry negative charges.
- Transdermal delivery efficacy of the modified AuNPs was evaluated in the context of wound repair.
Main Results:
- The developed VEGF-conjugated AuNPs demonstrated ideal transdermal delivery efficacy.
- The negatively charged surface of the AuNPs facilitated efficient passage through the skin barrier.
- The delivery system showed promise for promoting VEGF's therapeutic effects in wound healing.
Conclusions:
- Gold nanoparticle-mediated delivery of VEGF offers a promising strategy for treating skin injuries.
- This approach effectively overcomes the limitations of transdermal VEGF delivery.
- The findings open new therapeutic avenues for managing cutaneous injuries and promoting skin regeneration.
