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Related Experiment Video

Updated: Mar 23, 2026

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

560

Advances in Microenvironment-Responsive Biomaterials for Spinal Cord Injury Repair.

Dezun Ma1, Xiang Wu1, Yijun Ma1

  • 1Academy of Integrative Medicine, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China.

Advanced Healthcare Materials
|March 21, 2026
PubMed
Summary
This summary is machine-generated.

Spinal cord injury (SCI) biomaterials can respond to the injury microenvironment. These responsive materials neutralize harmful signals and enable targeted drug delivery for improved SCI treatment and regeneration.

Keywords:
drug deliverymicroenvironment‐responsive biomaterialspathological microenvironmentspinal cord injury

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Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Regenerative Medicine

Background:

  • Spinal cord injury (SCI) causes irreversible motor and sensory deficits due to a hostile pathological microenvironment.
  • Secondary injury triggers signals like pH changes, reactive oxygen species (ROS), inflammation, and altered biophysical cues.

Purpose of the Study:

  • To review microenvironment-responsive biomaterials for SCI treatment.
  • To discuss design principles, response mechanisms, and applications of these advanced biomaterials.

Main Methods:

  • Focuses on the design and characteristics of biomaterials that respond to SCI-specific signals.
  • Explores how these biomaterials recognize and neutralize pathological cues.
  • Examines the use of disease-specific signals for controlled drug release.

Main Results:

  • Microenvironment-responsive biomaterials can ameliorate the SCI pathological milieu.
  • These materials enhance treatment accuracy and effectiveness by responding to specific triggers.
  • Review summarizes recent advances, regeneration mechanisms, and preclinical applications.

Conclusions:

  • Microenvironment-responsive biomaterials offer a promising therapeutic strategy for SCI.
  • Further development and clinical translation are needed to address current challenges.
  • This review provides guidance for future advanced biomaterial-based SCI therapies.