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Updated: Mar 8, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
An efficient synthesis method targeted to a novel aziridine derivative of p-menthane from turpentine and its
Shou-Ji Zhu1,2,3,4, Shi-Chao Xu1,2,3, Zhen-Dong Zhao1,2,3
1a Institute of Chemical Industry of Forest Products , CAF , Nanjing , China.
Abstract:
A novel aziridine compound N-acetyl-1,2-azacyclo-p-menthane d was synthesised using turpentine as raw material and characterised by FT-IR, 1H NMR, 13C NMR, ESI+-MS and HRMS. The pre-emergence herbicidal activities of d and its synthetic intermediates cis- and trans-N,N'-diacetyl-p-menthane-1,8-diamine (b2 and b1) were determined. The result showed that d exhibited much higher herbicidal activities against annual ryegrass, Digitaria sanguinalis and Ixeris denticulate than b2 and b1. The IC50 of d against the root and shoot growth of these three plants were lower than 1 mmol L-1. In contrast, the IC50 of b1 and b2 against the root and shoot growth of these plants were more than 10 mmol L-1.
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