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Updated: Dec 10, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Synthesis and biological activity of pyridine acylhydrazone derivatives of isopimaric acid
Yan-Ju Lu1,2,3,4,5,6, Zhen-Dong Zhao1,2,3,4,5,6, Yu-Xiang Chen1,2,3,4,5,6
1Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing 210042, China.
Abstract:
Pyridine acylhydrazone derivatives of isopimaric acid were synthesized and characterized. The minimum inhibitory concentrations of the compounds against five bacteria were determined and most of the compounds displayed some degree of antibacterial activity. The results showed that antimicrobial activity against Streptococcus pneumoniae improved when halogen atoms were introduced into the isopimaric acid, especially when one bromine atom was introduced in the para-position of isopimaric acid. Compound isopimaric acid (5-bromo pyridine-2-formaldehyde) acylhydrazone exhibited a significant antitumorial activity against hepatocarcioma cells (HepG-2) and breast cancer cells (MDA-MB-231), with inhibition degrees of 74.21% and 70.39%, respectively, at 100 μM.[Formula: see text].
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