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p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

Shasha Tao1, Pengfei Liu1, Gang Luo1

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.

Molecular and Cellular Biology
|January 25, 2017
PubMed
Summary

The p97 protein complex is crucial for degrading the NRF2 protein, a key player in cellular defense against oxidative stress. Understanding this pathway opens new avenues for cancer therapy targeting p97 and NRF2.

Keywords:
KEAP1NRF2autophagycancer chemoresistanceoxidative stressp97proteasomeprotein quality controlubiquitylation

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