Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Warren Alpert Medical School of Brown University: Clinicopathologic Conference: September 20th, 2024. A Woman in her 20s with Abdominal Pain, Anemia and Thrombocytopenia.

Journal of Brown hospital medicine·2025

Same author

Metastatic Merkel Cell Carcinoma.

The Brown journal of hospital medicine·2025

Same author

CD5 expression in marginal zone lymphoma predicts differential response to rituximab or bendamustine/rituximab.

Leukemia & lymphoma·2021

Same author

Antifungal prophylaxis during 7 + 3 induction chemotherapy for acute myeloid leukemia is associated with improved survival, in a setting with low incidence of invasive mold infections.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2020

Same author

Orbital metastasis in inflammatory breast cancer.

The breast journal·2020

Same author

Identifying monoclonal gammopathy of undetermined significance in electronic health data.

Pharmacoepidemiology and drug safety·2019

Search research articles

Related Experiment Video

Updated: Mar 8, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Hypercalcemia due to Primary Hepatic Lymphoma.

Andrew Hsu¹, Michael Gagnier¹, Elizabeth Ryer¹

¹Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Case Reports in Hematology

|January 25, 2017

Summary

A persistent hypercalcemia case was investigated. Primary hepatic lymphoma was identified as the unexpected cause, despite treatment adjustments for osteoporosis.

Related Experiment Videos

Last Updated: Mar 8, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Area of Science:

Oncology
Endocrinology
Rheumatology

Background:

Mixed connective tissue disease and pulmonary fibrosis management often involves immunosuppressants.
Osteoporosis is a common comorbidity, frequently treated with bone-anabolic agents like teriparatide.

Observation:

A 65-year-old female presented with persistent hypercalcemia.
Hypercalcemia symptoms continued even after teriparatide discontinuation.

Findings:

Primary hepatic lymphoma was diagnosed as the underlying cause of hypercalcemia.
Malignancy-associated hypercalcemia can occur in hepatic lymphoma.

Implications:

Highlights the importance of considering rare causes of hypercalcemia in patients with autoimmune diseases.
Underscores the need for thorough diagnostic workups when hypercalcemia is refractory to standard treatments.
Emphasizes the potential for hepatic lymphoma to manifest with hypercalcemia.