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[Effects of MMPs inhibitors on microleakage with wet bonding technique]
1School of Stomatology, Jilin University. Changchun 130021, Jilin Province, China.
Purpose:
To observe the effects of matrix metalloproteinases(MMPs) inhibitors on microleakage with wet bonding technique.
Methods:
Twenty-seven premolars were randomly assigned to 3 groups. Class Ⅴ cavities were prepared in the neck of the teeth and treated with distilled water, 2% chlorhexidine (CHX) or 2% monocycline (MI) for 60 seconds. Resin was used to restore the prepared cavities following application of luting agent. Samples in each group were soaked for 1 h with 10% NaClO and then 2 layers of nail polish were applied, followed by treatment with 50wt% ammoniated silver nitrate (ASN), and developing solution in turn. Each tooth was sectioned longitudinally to 1~2 mm slices and examined with stereo microscope and scanning electron microscope (SEM). The data were analyzed with SPSS 16.0 software package for Wilcoxon rank sum test.
Results:
There was varied microleakage at the margin. The difference was significant between group CHX and control group, between group MI and control group; However, there was no significant difference between group CHX and group MI.
Conclusions:
MMPs inhibitor can reduce microleakage with wet bonding technique.
