Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Enhancing Coronary Artery Revascularization
05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

1.4K

Outcomes in Elderly Patients With Severely Calcified Coronary Lesions Undergoing Orbital Atherectomy

Michael S Lee1, Evan Shlofmitz2, Gentian Lluri1

  • 1UCLA Medical Center, Los Angeles, California.

Journal of Interventional Cardiology
|January 25, 2017
PubMed

Insights

Orbital atherectomy is a safe and effective treatment for elderly patients with severe coronary artery calcification (CAC). Outcomes were similar to younger patients, showing comparable rates of major adverse cardiac and cerebrovascular events (MACCE).

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Geriatric Cardiology

Background:

  • Percutaneous coronary intervention (PCI) in severe coronary artery calcification (CAC) is linked to poorer outcomes.
  • Elderly patients face higher risks and worse outcomes post-PCI due to comorbidities.
  • Orbital atherectomy's safety and efficacy in severe CAC are established, but outcomes in the elderly are unknown.

Purpose of the Study:

  • To evaluate the clinical outcomes of elderly patients undergoing orbital atherectomy for severe CAC.
  • To compare the safety and efficacy of orbital atherectomy in elderly versus younger patients.

Main Methods:

  • A cohort study comparing 229 elderly (≥75 years) and 229 younger (<75 years) patients.
  • Primary endpoint: 30-day major adverse cardiac and cerebrovascular events (MACCE), including death, myocardial infarction (MI), target vessel revascularization (TVR), and stroke.
  • Analysis of angiographic complications and stent thrombosis rates.

Main Results:

  • Similar 30-day MACCE rates in elderly and younger groups (2.2% vs. 2.2%, P=1).
  • Individual event rates (death, MI, TVR, stroke) were comparable between age groups.
  • Low and similar rates of angiographic complications and stent thrombosis observed in both elderly and younger cohorts.

Conclusions:

  • Orbital atherectomy is a safe and effective strategy for elderly patients with severe CAC.
  • Clinical outcomes in elderly patients treated with orbital atherectomy mirror those of younger patients.
  • Further clarification of orbital atherectomy's role in the elderly is warranted via randomized trials.
Abstract

More Related Videos

Three-Dimensional Reconstruction of Orbital Fractures08:18

Three-Dimensional Reconstruction of Orbital Fractures

Published on: May 16, 2025

805

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
540
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
357
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
472