Related Experiment Video
Updated: Mar 8, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Nuclear Molecular and Theranostic Imaging for Differentiated Thyroid Cancer
Arif Sheikh1, Berna Polack, Yvette Rodriguez
1Columbia University Medical Center, Clinic of Radiology, New York, USA, Phone: +1 212 305 9335,
Abstract:
Traditional nuclear medicine is rapidly being transformed by the evolving concepts in molecular imaging and theranostics. The utility of new approaches in differentiated thyroid cancer (DTC) diagnostics and therapy has not been fully appreciated. The clinical information, relevant to disease management and patient care, obtained by scintigraphy is still being underestimated. There has been a trend towards moving away from the use of radioactive iodine (RAI) imaging in the management of the disease. This paradigm shift is supported by the 2015 American Thyroid Association Guidelines (1). A more systematic and comprehensive understanding of disease pathophysiology and imaging methodologies is needed for optimal utilization of different imaging modalities in the management of DTC. There have been significant developments in radiotracer and imaging technology, clinically proven to contribute to the understanding of tumor biology and the clinical assessment of patients with DTC. The research and development in the field continues to evolve, with expected emergence of many novel diagnostic and therapeutic techniques. The role for nuclear imaging applications will continue to evolve and be reconfigured in the changing paradigm. This article aims to review the clinical uses and controversies surrounding the use of scintigraphy, and the information it can provide in assisting in the management and treatment of DTC.
Insights
Nuclear medicine advances molecular imaging for differentiated thyroid cancer (DTC). Scintigraphy offers valuable clinical insights for DTC management, despite a trend away from radioactive iodine (RAI) imaging.
Area of Science:
- Nuclear medicine
- Molecular imaging
- Theranostics
Background:
- Traditional nuclear medicine is evolving with molecular imaging and theranostics.
- The role of scintigraphy in differentiated thyroid cancer (DTC) diagnostics and therapy is often underestimated.
- A paradigm shift is occurring, moving away from radioactive iodine (RAI) imaging in DTC management, supported by recent guidelines.
Purpose of the Study:
- To review the clinical utility and controversies of scintigraphy in differentiated thyroid cancer (DTC).
- To highlight the importance of understanding disease pathophysiology and imaging methodologies for optimal DTC management.
- To discuss the evolving role of nuclear imaging in light of technological advancements.
Main Methods:
- Review of current literature on scintigraphy in differentiated thyroid cancer (DTC).
- Analysis of clinical information provided by scintigraphy for disease management.
- Discussion of advancements in radiotracer and imaging technology.
Main Results:
- Scintigraphy provides valuable clinical information for DTC patient care that is currently underestimated.
- Significant developments in radiotracer and imaging technology enhance the understanding of tumor biology.
- The field is rapidly evolving with new diagnostic and therapeutic techniques emerging.
Conclusions:
- A comprehensive understanding of DTC pathophysiology and imaging is crucial for optimal patient care.
- Scintigraphy remains a relevant tool in DTC management, despite evolving trends.
- Nuclear imaging applications will continue to adapt and play a vital role in the changing landscape of DTC treatment.
Related Concept Videos
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Isotopes and Radioisotopes
An isotope containing...

