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Updated: Mar 8, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.6K
Mortality in patients with psoriasis. A retrospective cohort study
Walter Masson1, Emiliano Rossi1, María Laura Galimberti1
1Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Medicina Clinica
|January 26, 2017
Summary
Patients with psoriasis have a higher prevalence of cardiovascular risk factors and increased mortality rates compared to the general population. This study highlights the significant association between psoriasis and elevated mortality risks.
Area of Science:
- Immunodermatology
- Cardiovascular Medicine
- Epidemiology
Background:
- Psoriasis involves immune and inflammatory pathways that may promote atherosclerosis.
- Increased mortality is a concern in psoriasis patients due to potential cardiovascular complications.
Purpose of the Study:
- To compare mortality rates in psoriasis patients versus a control group.
- To determine the prevalence of cardiovascular risk factors in individuals with psoriasis.
Main Methods:
- Retrospective cohort study using electronic medical records.
- Inclusion of 1,481 psoriasis patients and 1,500 controls, excluding those with prior cardiovascular disease.
- Survival analysis with follow-up until June 2015, analyzing all-cause mortality.
Main Results:
- Psoriasis patients exhibited a higher prevalence of cardiovascular risk factors.
- Mortality rates were significantly higher in the psoriasis group (15.1 per 1,000 person-years) compared to controls (9.6 per 1,000 person-years).
- Psoriasis was independently associated with increased mortality (HR 1.48, P=.014) after adjusting for risk factors.
Conclusions:
- Psoriasis patients demonstrate a greater predisposition to cardiovascular risk factors.
- The study confirms a higher mortality rate among individuals with psoriasis during the follow-up period.
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