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Updated: Mar 8, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Progress in Enantioselective Radical Cyclizations.
Hideto Miyabe1, Akira Kawashima1, Eito Yoshioka1
1School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Chuo-ku, Kobe, 650-8530, Japan.
This review details advancements in enantioselective radical cyclization, focusing on controlling stereochemistry in organic synthesis. Key methods include chiral Lewis acids and organocatalysis for creating complex molecules.
Area of Science:
- Organic Chemistry
- Stereoselective Synthesis
Background:
- Controlling stereoselectivity in radical reactions is crucial for organic synthesis.
- Emerging strategies continuously advance stereochemical control in radical reactions.
Purpose of the Study:
- To highlight recent progress in enantioselective radical cyclization reactions.
- To summarize various methods for controlling stereochemistry in these reactions.
Main Methods:
- Chiral Lewis acid-catalyzed enantioselective radical cyclizations.
- Enantioselective organocatalysis for radical reactions.
- Use of chiral metallic reagents, imidazolidinone catalysts, non-covalent organocatalysts, and chiral thiols.
Main Results:
- Chiral Lewis acid catalysis was initially central to enantioselective radical cyclizations.
- Significant progress has been achieved in enantioselective organocatalysis.
- Successful examples for enantioselective radical cyclizations remain limited compared to intermolecular reactions.
Conclusions:
- The review summarizes key developments in enantioselective radical cyclization.
- Various catalytic systems, including organocatalysts, are discussed for stereochemical control.
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