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Updated: Mar 8, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Macular hole in Stargardt disease: Clinical and ultra-structural observation
Stanislao Rizzo1, Dario Pasquale Mucciolo1, Daniela Bacherini1
1a Department of Translational Surgery and Medicine , Eye Clinic, University of Florence , Florence , Italy.
Purpose:
To report for the first time a case report of a Stargardt disease patient who developed a macular hole (MH) which was treated with a surgical approach.
Method:
Case report.
Results:
After vitrectomy a complete closure of the MH was obtained and the best-corrected visual acuity remained stable. No complications were reported after one year of follow-up. An ultra-structural examination of the removed internal limiting membrane (ILM) and epiretinal membrane (ERM) was carried out under electron microscopy.
Conclusion:
Vitreo-retinal surgery could represent a therapeutic option to treat vitreo-retinal interface abnormalities associated with inherited retinal diseases.

