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Destructive effect of HIFU on rabbit embedded endometrial carcinoma tissues and their vascularities
1Department of Obstetrics and Gynaecology, Zhabei District Central Hospital, Zhabei District, Shanghai 200000, China.
Objectives:
To evaluate damage effect of High-intensity focused ultrasound on early stage endometrial cancer tissues and their vascularities.
Materials And Methods:
Rabbit endometrial cancer models were established via tumor blocks implantation for a prospective control study. Ultrasonic ablation efficacy was evaluated by pathologic and imaging changes. The target lesions of experimental rabbits before and after ultrasonic ablation were observed after autopsy. The slides were used for hematoxylin-eosin staining, elastic fiber staining and endothelial cell staining; the slides were observed by optical microscopy. One slide was observed by electron microscopy. Then the target lesions of experimental animals with ultrasonic ablation were observed by vascular imaging, one group was visualized by digital subtract angiography, one group was quantified by color Doppler flow imaging, and one group was detected by dye perfusion.SPSS 19.0 software was used for statistical analyses.
Results:
Histological examination indicated that High-intensity focused ultrasound caused the tumor tissues and their vascularities coagulative necrosis. Tumor vascular structure components including elastic fiber, endothelial cells all were destroyed by ultrasonic ablation. Digital subtract angiography showed tumor vascular shadow were dismissed after ultrasonic ablation. After ultrasonic ablation, gray-scale of tumor nodules enhanced in ultrasonography, tumor peripheral and internal blood flow signals disappeared or significantly reduced in color Doppler flow imaging. Vascular perfusion performed after ultrasonic ablation, tumor vessels could not filled by dye liquid.
Conclusion:
High-intensity focused ultrasound as a noninvasive method can destroy whole endometrial cancer cells and their supplying vascularities, which maybe an alternative approach of targeted therapy and new antiangiogenic strategy for endometrial cancer.
Insights
High-intensity focused ultrasound effectively destroys early-stage endometrial cancer tissues and their blood vessels. This noninvasive method offers a potential new targeted therapy and anti-angiogenic strategy for endometrial cancer.
Area of Science:
- Oncology
- Medical Imaging
- Biomedical Engineering
Background:
- Endometrial cancer requires effective treatment strategies.
- Targeted therapies and anti-angiogenic approaches are crucial for improving outcomes.
Purpose of the Study:
- To assess the impact of High-intensity focused ultrasound (HIFU) on early-stage endometrial cancer and its vascular supply.
- To evaluate HIFU's efficacy in destroying tumor tissues and associated vasculature.
Main Methods:
- Rabbit endometrial cancer models were utilized.
- Pathologic and imaging techniques, including hematoxylin-eosin staining, elastic fiber staining, endothelial cell staining, electron microscopy, digital subtract angiography, color Doppler flow imaging, and dye perfusion, were employed.
- Statistical analyses were performed using SPSS 19.0.
Main Results:
- High-intensity focused ultrasound induced coagulative necrosis in tumor tissues and vascular structures.
- Ultrasonic ablation destroyed elastic fibers and endothelial cells within tumor vasculature.
- Imaging studies confirmed the disappearance of tumor vascular shadows and reduced blood flow post-HIFU treatment.
Conclusions:
- High-intensity focused ultrasound is a noninvasive method capable of eradicating endometrial cancer cells and their vascular networks.
- HIFU presents a promising alternative for targeted therapy in endometrial cancer.
- This technique may serve as a novel anti-angiogenic strategy for managing endometrial cancer.
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