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Updated: Mar 8, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Potential Dose to Nuclear Medicine Technologists from 99mTc-DTPA Aerosol Lung Studies
Bryan Achey1, Ken Miller, Mike Erdman
1* Penn State Hershey Medical Center, Hershey, PA 17033.
Abstract:
Air sampling performed during 190 Tc-labeled DTPA aerosol lung ventilation studies indicated that the maximum airborne concentration to which the nuclear medicine technologists might be exposed was 7.1 × 10 Bq mL (1.9 × 10 μCi mL). If a single technologist performed ALL the aerosol studies, at this maximum airborne concentration, based on the Annual Limit on Intake (ALI), the resulting dose equivalents could be either 1 mSv (100 mrem) to the lungs or 0.1 mSv (10 mrem) to the total body. However, the procedures are shared by the technical staff, the times of exposure are represented by only a fraction of the overall procedure time, and the average airborne concentrations were found to be more than an order of magnitude lower than the maximum. This resulted in a projected average annual dose equivalent of 7.0 × 10 mSv (0.7 mrem) to the lungs or 7.0 × 10 mSv (0.07 mrem) to the whole body from the performance of these procedures.
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