Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.6K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deferoxamine Improves Radiation-Induced Peripheral Neuropathy.

Journal of cellular and molecular medicine·2026
Same author

Comparative Analysis of Hospital Charges in Infants With Robin Sequence: Nonsurgical Orthodontic Airway Plate Versus Surgical Mandibular Distraction.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

Psychosocial Outcomes of the Stanford Orthodontic Airway Plate (OAP) Treatment in Caregivers and Children With Pierre Robin Sequence.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

A Pan-Cancer Single-Cell Atlas to Evaluate Tumor Identity, Cell Line Concordance, and Dependency Mapping.

bioRxiv : the preprint server for biology·2026
Same author

Metabolic Effects on Wound Healing.

Advances in wound care·2026
Same author

A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation.

Journal of visualized experiments : JoVE·2026

Related Experiment Video

Updated: Mar 8, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
08:35

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

20.4K

Excess Dermal Tissue Remodeling In Vivo: Does It Settle?

Tripp Leavitt1,2, Michael S Hu1,2, Elizabeth R Zielins1,2

  • 1Stanford, Calif.; and Boston, Mass.

Plastic and Reconstructive Surgery
|January 26, 2017
PubMed
Summary
This summary is machine-generated.

Excess skin tissue remodels by flattening and increasing collagen, but does not fully return to its original size. These findings in mice suggest potential implications for human wound healing.

More Related Videos

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

8.9K
Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

13.0K

Related Experiment Videos

Last Updated: Mar 8, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
08:35

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

20.4K
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

8.9K
Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

13.0K

Area of Science:

  • Dermatology
  • Tissue Engineering
  • Wound Healing Research

Background:

  • Surgical skin manipulation can cause excess tissue puckering.
  • This excess tissue is often assumed to resolve naturally over time.
  • The remodeling process of this excess tissue is not well understood.

Purpose of the Study:

  • To investigate the remodeling process of excess dermal tissue created by surgical manipulation.
  • To determine the long-term effects of induced tissue deformities on skin area and composition.

Main Methods:

  • Excess tissue deformities were created in mice using purse-string sutures under tension.
  • Control mice had sutures placed without tension.
  • Skin area was measured post-suture removal, with histological analysis performed.

Main Results:

  • Excess tissue deformities flattened within 2 days after suture removal.
  • Treated skin showed a significant decrease in area (18% at 14 days) compared to controls.
  • Histology revealed increased collagen and myofibroblasts in the deformed skin.

Conclusions:

  • Induced excess dermal tissue remodels via flattening and increased collagen deposition.
  • The skin does not fully re-expand to its original baseline area after deformation.
  • Further research is needed to ascertain if these findings translate to human tissue remodeling.