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T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Updated: Mar 8, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Interluekin-17A (IL17A).

Kong Chen¹, Jay K Kolls¹

¹Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.

|January 26, 2017

Summary

This summary is machine-generated.

Interleukin-17A (IL-17A) plays crucial roles in autoimmune diseases and host defense. Targeting the IL-17A pathway with biological agents has shown promise in treating conditions like psoriasis.

Keywords:

Cancer Inflammation Interleukin-17A Neutrophil

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

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Published on: October 25, 2024

Area of Science:

Immunology
Inflammation Research
Drug Discovery

Background:

Interleukin-17A (IL-17A) and IL-17A-producing cells are implicated in inflammation, autoimmune diseases, and host defense.
Th17 cells, a distinct CD4+ T helper cell lineage, are key producers of IL-17A and represent a potential therapeutic target.
The IL-17A pathway is targeted by biological agents, including those inhibiting IL-17A or its upstream regulator IL-23.

Purpose of the Study:

To review the discovery and fundamental roles of IL-17A.
To explore the receptors utilized by IL-17A.
To elucidate the involvement of IL-17A in mucosal immunity and inflammatory processes.

Main Methods:

Literature review of scientific publications.
Analysis of preclinical and clinical studies involving IL-17A pathway modulation.
Examination of data on IL-17A's function in host defense and inflammatory conditions.

Main Results:

IL-17A is essential for host defense against extracellular bacteria and fungi.
Targeting IL-17A has proven effective, with anti-IL-17A therapy approved for psoriasis treatment.
IL-17A pathway inhibition is a validated therapeutic strategy for specific inflammatory diseases.

Conclusions:

IL-17A is a critical cytokine in immunity and inflammation, with significant implications for autoimmune diseases.
The IL-17A pathway represents a successful target for therapeutic intervention in various inflammatory conditions.
Further understanding of IL-17A's mechanisms can lead to novel treatment strategies.