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Epidermal growth factor receptor not equal to nerve growth factor
1CNS Diseases Research, Upjohn Company, Kalamazoo, MI 49001.
Neurobiology of Aging
|September 1, 1989
Abstract:
I am perplexed by the authors' complete lack of definition of neurotrophic factors. The agents Butcher and Woolf want to blame are neurite promoting factors, not neurotrophic factors. Treatment of Alzheimer's disease with NGF antagonists might instead exacerbate the death of both basal forebrain neurons and their cortical target neurons, accelerating the progress of dementia.