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The mTORC1 Complex Is Significantly Overactivated in SDHX-Mutated Paragangliomas

Lindsey Oudijk1, Thomas Papathomas, Ronald de Krijger

  • 1Department of Pathology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.

Neuroendocrinology
|January 26, 2017
PubMed
Summary

The mTOR pathway is activated in pheochromocytomas and paragangliomas. mTORC1 complex is preferentially overactivated in head and neck paragangliomas, particularly those with SDHX mutations.

Keywords:
ParagangliomaPheochromocytomaSuccinate dehydrogenase complexmTOR

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