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Clinical features and management of Plasmodium knowlesi infections in humans

Cyrus Daneshvar1, Timothy William2, Timothy M E Davis3

  • 1Department of Respiratory Medicine,Plymouth Hospitals NHS Trust,Plymouth,UK.

Parasitology
|January 27, 2017
PubMed

Insights

Plasmodium knowlesi, a simian malaria parasite, is increasingly recognized as a significant human pathogen in Southeast Asia. This review details the disease and its treatment, highlighting its growing public health importance.

Area of Science:

  • Tropical medicine
  • Infectious diseases
  • Parasitology

Background:

  • Plasmodium knowlesi is a simian malaria parasite native to macaques in Southeast Asia.
  • Human infections were historically considered rare, primarily occurring during malariotherapy.
  • In 2004, P. knowlesi emerged as a significant cause of human malaria in Sarawak, Malaysian Borneo.

Purpose of the Study:

  • To provide a comprehensive review of current literature on Plasmodium knowlesi.
  • To describe the epidemiology, clinical presentation, and treatment of human knowlesi malaria.
  • To enhance understanding of this potentially fatal zoonotic disease.

Main Methods:

  • Systematic review of clinical studies and literature published over the last 12 years.
  • Analysis of data on disease prevalence, clinical manifestations, and therapeutic interventions.
  • Synthesis of current knowledge regarding Plasmodium knowlesi infections in humans.

Main Results:

  • Plasmodium knowlesi is now a recognized cause of human malaria across Southeast Asia.
  • Infections affect both residents and travelers in endemic regions.
  • Clinical studies have significantly advanced the understanding of this zoonotic disease over the past decade.

Conclusions:

  • Plasmodium knowlesi represents an emerging infectious disease threat in Southeast Asia.
  • Prompt diagnosis and appropriate treatment are crucial for managing knowlesi malaria.
  • Continued research is essential to address the public health implications of this parasite.
Keywords:
Plasmodium knowlesiantimalarialclinicalcomplicatedmalariaseveresimiantreatment

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