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Updated: Mar 8, 2026
Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration
Published on: May 5, 2020
Effects of agmatine sulphate on facial nerve injuries
O Surmelioglu1, L Sencar2, S Ozdemir1
1Department of Otorhinolaryngology,Cukurova University,Adana,Turkey.
Objective:
To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.
Methods:
The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.
Results:
Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004).
Conclusion:
Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration.
