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Microfluidics in Assessing Platelet Function
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Relationship between platelet indices in acute cholecystitis: A case-control study.

S Özdemir1, I Altunok1, A Özkan2

  • 1Departamento de Medicina de Urgencias, Universidad de Ciencias de la Salud, Hospital de Investigación y Capacitación de Umraniye, Estambul, Turkey.

Revista De Gastroenterologia De Mexico (English)
|July 7, 2023
PubMed
Summary

Initial mean platelet volume and platelet distribution width can help predict acute cholecystitis in emergency department patients. These platelet indices offer valuable insights for diagnosing this common gallbladder condition.

Keywords:
Ancho de la distribución plaquetariaCholecystitisColecistitisMean platelet volumePlaquetasPlatelet distribution widthPlatelet mass indexPlateletsVolumen plaquetario medioÍndice de masa plaquetaria

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Area of Science:

  • Medical diagnostics
  • Hematology
  • Gastroenterology

Background:

  • Acute cholecystitis is a common cause of emergency department visits.
  • Early diagnosis of acute cholecystitis is crucial for effective patient management.
  • Platelet indices are readily available laboratory parameters that may aid in diagnosis.

Purpose of the Study:

  • To investigate initial platelet indices in patients with acute cholecystitis.
  • To determine if platelet indices can serve as predictors for acute cholecystitis.

Main Methods:

  • Retrospective case-control study involving 553 acute cholecystitis patients and 541 controls.
  • Collected demographic, comorbidity, laboratory, and clinical outcome data.
  • Analyzed platelet count, mean platelet volume (MPV), plateletcrit, platelet distribution width (PDW), and platelet mass index.

Main Results:

  • Mean platelet volume (MPV) and platelet distribution width (PDW) were significantly different between acute cholecystitis patients and controls.
  • Multivariate analysis identified MPV and PDW as independent predictors (aOR 2, p<0.001 and aOR 5.88, p<0.001).
  • A predictive model using these indices achieved high accuracy (91.7%), sensitivity (89%), and specificity (94.5%) with an AUC of 0.969.

Conclusions:

  • Initial mean platelet volume (MPV) and platelet distribution width (PDW) are independent predictors of acute cholecystitis.
  • These platelet indices can be valuable tools for the early detection of acute cholecystitis.
  • The findings support the use of MPV and PDW in diagnostic algorithms for acute cholecystitis.