Related Experiment Video
Updated: Mar 8, 2026
08:52
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
3.6K
Cellular senescence in osteoarthritis pathology
Kendal McCulloch1, Gary J Litherland1, Taranjit Singh Rai1
1Institute of Biomedical and Environmental Health Research, University of the West of Scotland, Paisley, PA1 2BE, UK.
Aging Cell
|January 27, 2017
Summary
Cellular senescence, a state of cell cycle arrest, contributes to age-related diseases. This review explores how senescent cells may drive osteoarthritis (OA) development and progression.
Area of Science:
- Cellular and Molecular Biology
- Gerontology
- Rheumatology
Background:
- Cellular senescence is a protective mechanism against cellular damage.
- Persistent senescent cells can impair tissue function and contribute to aging diseases.
- Osteoarthritis (OA) is a prevalent age-related joint disease.
Purpose of the Study:
- To review the role of cellular senescence in osteoarthritis pathogenesis.
- To explore mechanisms linking senescent cells to OA development and progression.
- To discuss epigenetic alterations in OA and senescence.
Main Methods:
- Literature review of cellular senescence and osteoarthritis.
- Analysis of senescence markers in OA chondrocytes.
- Discussion of secretory profiles of senescent cells and OA mediators.
Main Results:
- Senescent cells accumulate in OA joint tissues.
- OA pathogenesis shares similarities with the secretory profile of senescent cells.
- Chondrocytes in OA exhibit increased senescence markers (e.g., SAβGal, p16ink4a).
Conclusions:
- Cellular senescence is hypothesized to play a pathological role in OA.
- Senescent cells may predispose synovial joints to OA development and progression.
- Epigenetic alterations are associated with both OA and cellular senescence.
More Related Videos
12:23Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
Published on: April 24, 2020
21.3K
08:42Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
Published on: January 7, 2019
7.3K
Related Concept Videos
01:19The Effect of Aging on Tissues
4.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.0K
01:29Bone Disorders
5.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.8K
01:26Aging
929
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
929
02:15Replicative Cell Senescence
4.5K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.5K
01:40Bone Remodeling
40.8K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.8K
01:37Mitochondria
21.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.1K