Related Experiment Video
Updated: May 4, 2026
08:43
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
7.5K
Sendotypes predict worsening renal function in chronic kidney disease patients
Thomas McLarnon1, Steven Watterson1, Sean McCallion1
1School of Medicine, Personalised Medicine Centre, Ulster University, Londonderry, UK.
Clinical and Translational Medicine
|March 27, 2025
Summary
Senescence signatures identify distinct patient groups in Chronic Kidney Disease (CKD). This discovery may help predict disease progression and improve patient care pathways for CKD.
Area of Science:
- Gerontology
- Nephrology
- Proteomics
Background:
- Senescence-associated secretory phenotype (SASP) is implicated in aging, but its role in Chronic Kidney Disease (CKD) remains undefined.
- This study investigates the potential of SASP to classify CKD patients into distinct endotypes.
Purpose of the Study:
- To determine if senescence signatures can stratify CKD patients into distinct endotypes.
- To explore the clinical and molecular differences between these identified endotypes.
Main Methods:
- Utilized omic techniques to analyze senescent protein expression in CKD patients.
- Employed clustering algorithms to group patients into distinct senescence endotypes (Sendotypes).
- Performed differential expression analysis to identify key molecular pathways between Sendotypes.
Main Results:
- CKD patients were successfully stratified into two distinct Sendotypes based on proteomic data.
- Each Sendotype exhibited unique clinical profiles, with higher senescent protein expression correlating with more severe disease.
- Differential enrichment of pathways like TNF, JAK-STAT, and NFKB was observed between Sendotypes.
Conclusions:
- Senescence signatures, combined with clinical data, can accurately stratify CKD patients.
- This stratification may predict renal trajectory, aiding in personalized CKD management.
- The findings offer potential for improved clinical care pathways and accurate patient stratification in CKD.
Related Concept Videos
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
271
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271
01:19Multiple Sclerosis l: Introduction
20
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
20
01:29Alzheimer Disease l: Introduction
21
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
21
01:21Huntington Disease l: Introduction
110
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
110
01:22Dementia l: Introduction
35
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
35