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Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale
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Frequency-controlled wireless shape memory polymer microactuator for drug delivery application.

M A Zainal1, A Ahmad1, M S Mohamed Ali2

  • 1Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia.

Biomedical Microdevices
|January 27, 2017
PubMed
Summary
This summary is machine-generated.

This study presents a wireless Shape-Memory-Polymer actuator for drug delivery, activated by radio frequency magnetic fields. The device demonstrates controlled drug release in water, showcasing its potential for targeted therapeutic applications.

Keywords:
Drug delivery deviceLC circuitMEMSMicroactuatorsMicrofabricationShape memory polymerWireless power transfer

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Area of Science:

  • Polymer Science
  • Biomedical Engineering
  • Materials Science

Background:

  • Shape-Memory-Polymers (SMPs) offer tunable actuation for biomedical devices.
  • Wireless control is desirable for minimally invasive applications.
  • Existing wireless actuation methods often involve complex fabrication or limited control.

Purpose of the Study:

  • To develop and characterize a novel wireless SMP actuator.
  • To demonstrate its application in a drug delivery system.
  • To investigate the performance of a simplified fabrication method for the wireless heater.

Main Methods:

  • Fabrication of a frequency-sensitive wireless resonant heater using double-sided Cu-clad Polyimide.
  • Integration of the heater with an SMP actuator.
  • Wireless activation using external radio frequency magnetic fields.
  • Characterization of actuation range, temperature response, and repeatability.
  • Demonstration of drug release from a reservoir in an aqueous environment.

Main Results:

  • Achieved an actuation range of 140 μm at 44°C in 30s with 0.05 W RF power.
  • Demonstrated repeatable actuation with an average displacement of 110 μm (SD=12 μm).
  • Successfully released 5 μL of acidic solution in DI water wirelessly, with an average release rate of 0.172 μL/min.

Conclusions:

  • The developed wireless SMP actuator, driven by a simple resonant heater, is effective for controlled actuation.
  • The device shows promise for wireless drug delivery applications, even in aqueous environments.
  • The simplified fabrication process offers a practical advantage for device realization.