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Updated: Mar 8, 2026

Measurement of Chitinase Activity in Biological Samples
Published on: August 22, 2019
Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review
Jingqian Su1,2,3, Huiying Liu4,5,6, Kai Guo7,8,9
1Fujian Key Laboratory of Innate Immune Biology, Fujian Normal University, Fuzhou 350117, China. sjq027@fjnu.edu.cn.
Abstract:
Acetylcholinesterase inhibitors (AChEIs) are an attractive research subject owing to their potential applications in the treatment of neurodegenerative diseases. Fungi and bacteria are major producers of AChEIs. Their active ingredients of fermentation products include alkaloids, terpenoids, phenylpropanoids, and steroids. A variety of in vitro acetylcholinesterase inhibitor assays have been developed and used to measure the activity of acetylcholinesterases, including modified Ellman's method, thin layer chromatography bioautography, and the combined liquid chromatography-mass spectrometry/modified Ellman's method. In this review, we provide an overview of the different detection methodologies, the microbe-derived AChEIs, and their producing strains.
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